Molecular Diagnosis of Joint Infections


  • Infection following arthroplasty can be difficult to diagnose and treat
    • Infection occurs in 1-2% of primary total knee arthroplasty and 3-5% of revisions
    • Management of infected arthroplasty‚Äôs are complex, expensive and often require additional surgical intervention with prolonged hospital admission
  • Septic arthritis of native joints is on the rise as population ages
  • Recent studies show that microbiology culture only identifies 50% of symptomatic infections (False negative)
  • Biomarker assays that look at proteins associated with infection cannot identify the causative agent of infection


  • Compass Laboratory Services offers state of the art molecular diagnostic methods for identification of clinically relevant pathogens
    • Polymerase chain reaction (PCR) offers clinicians the highest degree of sensitivity that is not affected by inhibitors found in the synovial fluid
    • Faster turn around time as compared to traditional microbiology culture. Results

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